Characteristic Classes of Bad Orbifold Vector Bundles

We show that every bad orbifold vector bundle can be realized as the restriction of a good orbifold vector bundle to a suborbifold of the base space. We give an explicit construction of this result in which the Chen-Ruan orbifold cohomology of the two base spaces are isomorphic (as additive groups). This construction is used to indicate an extension of the Chern-Weil construction of characteristic classes to bad orbifold vector bundles. In particular, we apply this construction to the orbifold Euler class and demonstrate that it acts as an obstruction to the existence of nonvanishing sections.Comment: 12 pages; improved expositio

The Diabetic Dog as a Translational Model for Human Islet Transplantation.

The dog model has served as the primary method for early development of many diabetes therapies, including pancreatic islet transplantation techniques and immunosuppressive protocols. Recent trends towards the use of monoclonal antibody therapies for immunosuppression in human islet transplantation have led to the increasing use of primate models with induced diabetes. In addition to induced-disease models in large animals, scientists in many fields are considering the use of naturally-occurring disease models in client-owned pets. This article will review the applicability of naturally-occurring diabetes in dogs as a translational model for developing islet transplantation in the human diabetic patient